Description

Oxazole, 4-(1,1-Dimethylethyl)-2-[1-[2-(Diphenylphosphino)Phenyl]-1-Methylethyl]-4,5-Dihydro-, (4S)- is a high-value, chiral organophosphorus ligand used in asymmetric catalysis. This compound matters for its ability to impart high enantioselectivity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer intermediates. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• As a chiral ligand in asymmetric hydrogenation, hydroformylation, and cross-coupling reactions.
• For the synthesis of enantiomerically pure pharmaceutical intermediates in drug discovery and development.
• In academic and industrial research to explore new catalytic methodologies.
• As a key component in catalyst systems for the production of agrochemicals and specialty chemicals.
• For the scale-up of catalytic processes from laboratory to pilot plant and production scale.

Basic Information

Product Name	Oxazole, 4-(1,1-Dimethylethyl)-2-[1-[2-(Diphenylphosphino)Phenyl]-1-Methylethyl]-4,5-Dihydro-, (4S)-
CAS No.	947618-07-7
Molecular Formula	C29H32NOP
Molecular Weight	441.55 g/mol
Synonyms	(4S)-4-tert-Butyl-2-[1-[2-(diphenylphosphino)phenyl]-1-methylethyl]-4,5-dihydrooxazole; (S)-4-tert-Butyl-2-[1-[2-(diphenylphosphino)phenyl]-1-methylethyl]-4,5-dihydrooxazole; (S)-t-Bu-PHOX; (S)-tert-ButylPHOX; (S)-2-[1-[2-(Diphenylphosphino)phenyl]-1-methylethyl]-4-(1,1-dimethylethyl)-4,5-dihydrooxazole; PHOX Ligand (S-tert-Butyl variant); Chiral Dihydrooxazole Phosphine Ligand
EINECS	Contact for details

Quality Control

Our high-purity chiral ligands are produced under strict quality control protocols to ensure batch-to-batch consistency and performance. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and chiral analysis to confirm chemical identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Due to its sensitivity, keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.