Description

Oxazole, 2-[1-[2-(Diphenylphosphino)Phenyl]-1-Methylethyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4S)- is a high-value, chiral organophosphorus-oxazole hybrid ligand. This compound matters because it is specifically designed for asymmetric catalysis, offering precise stereochemical control in the synthesis of complex organic molecules. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and fine chemical industries for creating enantiomerically pure intermediates and active pharmaceutical ingredients (APIs).

Application

• Asymmetric Hydrogenation: A key chiral ligand for the enantioselective reduction of prochiral olefins, ketones, and imines.
• Pharmaceutical Intermediate Synthesis: Enables the production of chiral building blocks for APIs in a highly selective manner.
• Cross-Coupling Catalysis: Can be utilized in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) where a chiral environment is beneficial.
• Asymmetric Allylic Substitution: Facilitates the formation of carbon-carbon and carbon-heteroatom bonds with high enantiomeric excess.
• Academic & Industrial R&D: Serves as a sophisticated tool for developing novel catalytic methodologies in research laboratories.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, flavors, and fragrances requiring specific chirality.

Basic Information

Product Name	Oxazole, 2-[1-[2-(Diphenylphosphino)Phenyl]-1-Methylethyl]-4,5-Dihydro-4-(1-Methylethyl)-, (4S)-
CAS No.	947618-06-6
Molecular Formula	C29H32NOP
Molecular Weight	441.55 g/mol
Synonyms	(4S)-2-[1-[2-(Diphenylphosphino)phenyl]-1-methylethyl]-4-(propan-2-yl)-4,5-dihydrooxazole; (S)-2-[1-[2-(Diphenylphosphino)phenyl]-1-methylethyl]-4-isopropyl-4,5-dihydrooxazole; (S)-2-(1-(2-(Diphenylphosphino)phenyl)-1-methylethyl)-4-isopropyl-4,5-dihydrooxazole; Chiral PHOX-type ligand; P,N-Ligand; Josiphos-type analog; Chiral oxazoline-phosphine ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral ligands is produced and tested under strict quality management to ensure exceptional purity and enantiomeric integrity, critical for catalytic performance. Standard quality parameters include HPLC purity, chiral HPLC assay for enantiomeric excess (ee), and 1H/31P/13C NMR for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. Keep the container in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.