Description

4-(Trifluoromethylthio)-Benzeneboronic Acid is a high-value organoboron building block characterized by its unique trifluoromethylthio (-SCF₃) functional group. This compound is essential for modern synthetic chemistry, enabling the efficient construction of complex molecules through versatile cross-coupling reactions. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl structures found in active pharmaceutical ingredients (APIs), especially those requiring the lipophilic and metabolically stable trifluoromethylthio moiety.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides where the -SCF₃ group can enhance biological activity and environmental stability.
• Material Science: Serves as a building block for creating advanced organic electronic materials, such as those used in OLEDs and semiconductors, where the boronic acid group allows for precise molecular assembly.
• Chemical Synthesis: Employed as a versatile reagent in medicinal chemistry and process R&D for the late-stage functionalization and diversification of compound libraries.
• Ligand & Catalyst Development: Useful in the synthesis of novel ligands and organometallic catalysts for asymmetric synthesis and other specialized catalytic processes.

Basic Information

Product Name	4-(Trifluoromethylthio)-Benzeneboronic Acid
CAS No.	947533-15-5
Molecular Formula	C₇H₆BF₃O₂S
Molecular Weight	221.99 g/mol
Synonyms	4-(Trifluoromethylthio)phenylboronic Acid; [4-(Trifluoromethylsulfanyl)phenyl]boronic Acid; Benzeneboronic acid, 4-[(trifluoromethyl)thio]-; p-(Trifluoromethylthio)phenylboronic Acid; 4-SCF3-Phenylboronic Acid; 4-(Trifluoromethylmercapto)benzeneboronic Acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethylthio)-Benzeneboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using an inert atmosphere or desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.