Description

Tipranavir Glucuronide is a key metabolite and reference standard of the antiretroviral drug Tipranavir. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily used by researchers and quality control laboratories in the pharmaceutical and biotechnology industries for analytical and regulatory purposes.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the identification and quantification of Tipranavir metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Critical for investigating the metabolic pathways, clearance rates, and bioavailability of Tipranavir.
• Bioanalytical Method Development: Used to validate HPLC, LC-MS, and LC-MS/MS methods for accurate therapeutic drug monitoring and clinical research.
• Impurity Profiling and Characterization: Employed as a known impurity or degradation product to ensure the purity and stability of Tipranavir drug substance and products.
• Regulatory Compliance and Submission: Supports regulatory filings (e.g., for FDA, EMA) by providing definitive data on drug metabolism for safety and efficacy assessments.

Basic Information

Product Name	Tipranavir Glucuronide
CAS No.	947408-14-2
Molecular Formula	C₃₈H₄₅F₃N₂O₁₀S
Molecular Weight	778.84 g/mol
Synonyms	Tipranavir Glucuronide; Tipranavir O-Glucuronide; 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, 3-[[(1R,5S,6S)-6-[[(3S,5R)-5-[[[(1,1-Dimethylethoxy)carbonyl]amino]-5-(2-oxo-1-pyrrolidinyl)-1-oxopentyl]amino]-2-(hydroxymethyl)-1-methyl-4,7-dioxobicyclo[3.2.0]hept-3-yl]thio]-6-fluoro-7-oxo-, (2R,3R)-2-[(β-D-Glucopyranuronosyl)oxy]-3-hydroxybutanedioate (1:1); PNU-140690 Glucuronide; Tipranavir β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Tipranavir Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for pharmaceutical reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.