Description

n-(Dicyclohexylphosphino)-2-(2'-methylphenyl)-1H-indole is a specialized, high-value organophosphorus ligand used in advanced catalytic processes. Its primary value lies in its ability to facilitate challenging cross-coupling and hydrogenation reactions with high selectivity and efficiency, which is critical for cost-effective and sustainable chemical synthesis. This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and fine chemical industries, particularly for the synthesis of complex, high-purity molecules.

Application

• Homogeneous Catalysis: As a key ligand in palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination) for C-C and C-N bond formation.
• Pharmaceutical Intermediate Synthesis: Enables the production of complex, nitrogen-containing heterocycles found in active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the catalytic synthesis of novel herbicides, fungicides, and insecticides requiring specific stereochemistry.
• Asymmetric Hydrogenation: Serves as a chiral ligand precursor for the synthesis of enantiomerically pure compounds.
• Material Science Research: Applied in the development of novel organometallic complexes and catalysts for polymer synthesis.
• Academic & Industrial R&D: A valuable tool for methodology development and exploring new catalytic transformations in laboratory settings.

Basic Information

Product Name	n-(Dicyclohexylphosphino)-2-(2'-methylphenyl)-1H-indole
CAS No.	947402-59-7
Molecular Formula	C27H34NP
Molecular Weight	403.54 g/mol
Synonyms	2-(2'-Methylphenyl)-1H-indol-1-yl-dicyclohexylphosphine; Dicyclohexyl[2-(2-methylphenyl)-1H-indol-1-yl]phosphine; N-(Dicyclohexylphosphino)-2-(2'-methylphenyl)indole; Buchwald-type indole phosphine ligand; Indole-based phosphine ligand; DCyP(2-MePh)Ind; (2-(o-Tolyl)-1H-indol-1-yl)dicyclohexylphosphine
EINECS	Contact for details

Quality Control

Every batch of our n-(Dicyclohexylphosphino)-2-(2'-methylphenyl)-1H-indole is manufactured and tested under strict quality management protocols to ensure high purity, lot-to-lot consistency, and reliable performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (HPLC/NMR), identity confirmation, and residual solvent content. Our quality systems are designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.