Description

N5-[(1,1-Dimethylethoxy)Carbonyl]-N2-[(2-Propen-1-Yloxy)Carbonyl]-L-Ornithine is a protected derivative of the amino acid L-ornithine, featuring both Boc (tert-butoxycarbonyl) and Alloc (allyloxycarbonyl) protecting groups on its side chain and α-amine, respectively. This compound is a critical building block in advanced organic synthesis, particularly for the controlled, sequential assembly of complex peptides and peptidomimetics. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic tools, and biochemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key, orthogonally protected amino acid building block for the controlled introduction of L-ornithine residues.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, including antimicrobial peptides, hormone analogs, and enzyme inhibitors.
• Bioconjugation Chemistry: The Alloc protecting group is selectively removable under mild, neutral conditions (e.g., using palladium catalysts), enabling its use in sophisticated bioconjugation and linker strategies.
• Combinatorial Chemistry Libraries: A valuable reagent for generating diverse libraries of compounds for high-throughput screening in drug discovery.
• Biochemical Research: Employed in studies of polyamine metabolism, enzyme-substrate interactions, and protein structure-function relationships.
• Custom Peptide Service: A fundamental component offered by CDMOs (Contract Development and Manufacturing Organizations) for producing client-specified peptide sequences.

Basic Information

Product Name	N5-[(1,1-Dimethylethoxy)Carbonyl]-N2-[(2-Propen-1-Yloxy)Carbonyl]-L-Ornithine
CAS No.	947401-26-5
Molecular Formula	C14H24N2O6
Molecular Weight	316.35 g/mol
Synonyms	Boc-Orn(Alloc)-OH; Nα-Alloc-Nδ-Boc-L-ornithine; (S)-2-((Allyloxy)carbonylamino)-5-((tert-butoxycarbonyl)amino)pentanoic acid; N2-Alloc-N5-Boc-L-ornithine; Boc-L-Orn(Alloc)-OH; Fmoc-Orn(Alloc)-OH precursor; L-Ornithine, N2-[(2-propen-1-yloxy)carbonyl]-, N5-[(1,1-dimethylethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our N5-[(1,1-Dimethylethoxy)Carbonyl]-N2-[(2-Propen-1-Yloxy)Carbonyl]-L-Ornithine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and spectroscopic identification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.