Description

4-(Benzyloxy)-1,2-Difluorobenzene is a high-purity fluorinated aromatic ether building block of significant interest in advanced organic synthesis. This compound matters as a versatile intermediate, enabling the precise introduction of fluorine and benzyl-protected oxygen functionalities into complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of fluorinated drug candidates, particularly in kinase inhibitors and CNS-active molecules.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the difluorobenzene moiety enhances bioavailability and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving dielectric anisotropy and stability.
• Polymer Chemistry: Acts as a monomer or modifier for introducing aromatic fluorine into high-performance polymers and resins.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to construct complex biaryl systems.
• Protecting Group Chemistry: The benzyloxy group can serve as a protecting group for phenols in multi-step synthetic sequences.

Basic Information

Product Name	4-(Benzyloxy)-1,2-Difluorobenzene
CAS No.	947279-22-3
Molecular Formula	C13H10F2O
Molecular Weight	220.22 g/mol
Synonyms	1,2-Difluoro-4-(phenylmethoxy)benzene; 4-Benzyloxy-1,2-difluorobenzene; 1,2-Difluoro-4-(benzyloxy)benzene; Benzene, 1,2-difluoro-4-(phenylmethoxy)-; 4-(Phenylmethoxy)-1,2-difluorobenzene; 2,3-Difluorophenyl benzyl ether
EINECS	Contact for details

Quality Control

Our 4-(Benzyloxy)-1,2-Difluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP and ISO guidelines ensures material traceability and reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.