Description

trans-1-(Boc-Amino)-4-Ethynylcyclohexane, 97% is a high-purity, protected amino acid derivative featuring a reactive alkyne handle, making it a versatile and critical building block in modern synthetic chemistry. Its primary value lies in enabling the efficient construction of complex molecular architectures through robust coupling reactions like click chemistry. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery, bioconjugation, and polymer synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and novel drug candidates, particularly for targeted therapies.
• Peptidomimetics & PROTACs: Used to incorporate cyclohexyl and alkyne motifs into peptide backbones and proteolysis-targeting chimeras (PROTACs) for enhanced stability and biological activity.
• Bioconjugation & Probe Development: The alkyne group enables efficient, site-specific labeling of biomolecules (proteins, antibodies, nucleic acids) via copper-catalyzed azide-alkyne cycloaddition (CuAAC) for diagnostics and imaging.
• Material Science & Polymer Chemistry: Serves as a functional monomer or cross-linker for creating specialty polymers, dendrimers, and smart materials with tailored properties.
• Chemical Biology & Library Synthesis: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in hit identification and lead optimization.
• Agrochemical Research: Employed in the design and synthesis of novel herbicides, fungicides, and plant growth regulators.

Basic Information

Product Name	trans-1-(Boc-Amino)-4-Ethynylcyclohexane, 97%
CAS No.	947141-86-8
Molecular Formula	C₁₃H₂₁NO₂
Molecular Weight	223.31 g/mol
Synonyms	trans-4-Ethynyl-1-((tert-butoxycarbonyl)amino)cyclohexane; 1-[(tert-Butoxycarbonyl)amino]-4-ethynylcyclohexane (trans); 4-Ethynylcyclohexylamine, N-Boc-protected; tert-Butyl (trans-4-ethynylcyclohexyl)carbamate; Boc-trans-4-ethynylcyclohexylamine; N-Boc-trans-4-ethynylcyclohexylamine; (trans)-N-(tert-Butoxycarbonyl)-4-ethynylcyclohexanamine
EINECS	Contact for details

Quality Control

Our trans-1-(Boc-Amino)-4-Ethynylcyclohexane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and meet the specified 97% purity standard. Certificates of Analysis (COA) detailing all test results are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.