Description

2'-(Fmoc-Aminomethyl)-Biphenyl-2-Carboxylic Acid CAS NO 946716-21-8 is a high-purity, protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound serves as a critical Fmoc-protected building block for the controlled introduction of a biphenyl moiety into peptide chains, enabling the development of novel peptide-based therapeutics and research tools. It is primarily utilized by pharmaceutical R&D teams, CROs, and fine chemical manufacturers engaged in the synthesis of complex peptides and peptidomimetics.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the automated or manual assembly of peptide sequences containing biphenyl amino acid analogs.
• Peptidomimetic Drug Discovery: Used to incorporate rigid, aromatic biphenyl structures into peptide backbones to enhance binding affinity, metabolic stability, and bioavailability.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for creating diverse libraries of peptide-like compounds for high-throughput screening.
• GPCR (G-Protein Coupled Receptor) Targeted Peptides: The biphenyl scaffold is often employed in the design of ligands for various GPCR targets.
• Research & Development: Fundamental research tool in academic and industrial labs studying protein-protein interactions and structure-activity relationships (SAR).
• API (Active Pharmaceutical Ingredient) Intermediate: A potential synthetic precursor in the multi-step manufacturing of peptide-based active ingredients.

Basic Information

Product Name	2'-(Fmoc-Aminomethyl)-Biphenyl-2-Carboxylic Acid
CAS No.	946716-21-8
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-Ambp-OH; 2'-(9-Fluorenylmethoxycarbonylaminomethyl)biphenyl-2-carboxylic Acid; N-[(2'-Carboxy[1,1'-biphenyl]-2-yl)methyl]-9H-fluoren-9-ylmethoxycarboxamide; 2'-(Fmoc-aminomethyl)-[1,1'-biphenyl]-2-carboxylic acid; 2'-(FmocNHCH2)-Biphenyl-2-COOH; Fmoc-2'-Amethyl-biphenyl-2-carboxylic Acid; (2'-{[(9H-Fluoren-9-ylmethoxy)carbonyl]aminomethyl}[1,1'-biphenyl]-2-yl)carboxylic Acid
EINECS	Contact for details

Quality Control

Our 2'-(Fmoc-Aminomethyl)-Biphenyl-2-Carboxylic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with the standards expected for pharmaceutical R&D and GMP-grade intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.