Description

Acetyl-Heme-Binding Protein 1 (1-21) (Human) CAS NO 946571-77-3 is a synthetic peptide fragment corresponding to the N-terminal region of the human acetyl-heme-binding protein 1, a key regulator in heme metabolism and cellular iron homeostasis. This high-purity peptide is essential for biochemical research, enabling the study of protein-protein interactions, heme trafficking mechanisms, and the development of diagnostic assays. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on hematology, metabolic disorders, and novel therapeutic target validation.

Application

• Biochemical Research: Used as a standard or reagent in studies investigating heme-binding affinity, protein structure-function relationships, and enzymatic activity assays.
• Diagnostic Development: Serves as a critical antigen or calibrator in the development of immunoassays (ELISA) for detecting biomarkers related to iron metabolism and related pathologies.
• Pharmaceutical R&D: Employed in high-throughput screening (HTS) platforms to identify and validate small molecule modulators or inhibitors targeting the heme-binding domain for drug discovery.
• Cell Signaling Studies: Applied in cellular models to elucidate the role of acetyl-heme-binding protein 1 in intracellular signaling pathways, oxidative stress response, and apoptosis.
• Antibody Production: Acts as an immunogen for generating specific polyclonal or monoclonal antibodies for research, diagnostic, and therapeutic applications.

Basic Information

Product Name	Acetyl-Heme-Binding Protein 1 (1-21) (Human)
CAS No.	946571-77-3
Molecular Formula	C115H179N33O34
Molecular Weight	~2500.8 g/mol (monoisotopic)
Synonyms	Acetyl-HBP1 (1-21); AHBP1 (1-21) peptide; N-terminal Acetylated Heme-Binding Protein 1 fragment; Human Acetyl-HBP1 peptide; Synthetic HBP1 peptide; CAS 946571-77-3; Ac-HBP1(1-21)
EINECS	Contact for details

Quality Control

Our Acetyl-Heme-Binding Protein 1 (1-21) (Human) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, amino acid analysis, and peptide content are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to minimize moisture absorption. Aliquot into smaller working quantities to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.