Description

Remdesivir-003-S CAS NO 946565-74-8 is a key pharmaceutical intermediate and reference standard in the synthesis of the antiviral drug Remdesivir. This compound is critical for ensuring the quality, consistency, and regulatory compliance of the final active pharmaceutical ingredient (API). It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories engaged in antiviral drug development and production.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of the antiviral API Remdesivir (GS-5734).
• Reference Standard: Used as a certified reference material (CRM) for quality control, method validation, and regulatory filings.
• Process Development & Scale-up: Essential for research and development (R&D) and process optimization in API manufacturing.
• Analytical Testing: Serves as a high-purity standard for HPLC, LC-MS, and NMR analysis to identify and quantify impurities.
• Regulatory Compliance: Supports the preparation of drug master files (DMFs) and investigational new drug (IND) applications.
• Academic & Biomedical Research: Used in studies investigating the mechanism of action and synthesis pathways of nucleotide analog antivirals.

Basic Information

Product Name	Remdesivir-003-S
CAS No.	946565-74-8
Molecular Formula	C27H35N6O8P
Molecular Weight	602.58 g/mol
Synonyms	GS-441524 monophosphate; (2S)-2-{(2R,3S,4R,5R)-[5-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethylbutyl ester; Remdesivir impurity; Remdesivir intermediate; GS-5734 intermediate; Veklury intermediate
EINECS	Contact for details

Quality Control

Our Remdesivir-003-S is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates and reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory support.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Chiral Purity	≥99.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.