Description

4-Difluoromethyl-Phenylboronic Acid is a high-value, multi-functional boronic acid derivative characterized by its difluoromethyl-substituted aromatic ring. This compound is a critical building block in modern synthetic chemistry, enabling the formation of carbon-carbon bonds via the versatile Suzuki-Miyaura cross-coupling reaction. It is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex molecules in drug discovery and development, particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for synthesizing functionalized polymers and organic electronic materials.
• Ligand and Catalyst Development: Employed in the creation of novel boron-containing ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Utilized in the design of activity-based probes and sensors for studying biological processes.

Basic Information

Product Name	4-Difluoromethyl-Phenylboronic Acid
CAS No.	946525-43-5
Molecular Formula	C7H7BF2O2
Molecular Weight	171.94 g/mol
Synonyms	4-(Difluoromethyl)benzeneboronic Acid; [4-(Difluoromethyl)phenyl]boronic Acid; (4-Difluoromethylphenyl)boronic Acid; 4-Difluoromethylbenzeneboronic Acid; p-Difluoromethylphenylboronic Acid; Boronic acid, B-[4-(difluoromethyl)phenyl]-; CAS 946525-43-5
EINECS	Contact for details

Quality Control

Our 4-Difluoromethyl-Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the stringent requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee traceability and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.