Description

(S)-Naproxen Acyl-β-D-Glucuronide Benzyl Ester CAS NO 946517-36-8 is a high-purity synthetic metabolite derivative of the non-steroidal anti-inflammatory drug (NSAID) naproxen. This compound serves as a critical reference standard and synthetic intermediate for advanced pharmaceutical research and development. It is primarily required by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of naproxen acyl glucuronide metabolites in biological matrices during clinical and non-clinical studies.
• Drug Metabolism & Pharmacokinetics (DMPK): Essential for investigating the metabolic pathways, stability, and pharmacokinetic profile of naproxen and related compounds.
• Analytical Method Development: Serves as a key analyte for developing and validating high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS/MS) methods in bioanalysis.
• Impurity Characterization: Employed to identify, qualify, and control potential genotoxic impurities or degradation products in naproxen drug substance and finished dosage forms.
• Synthetic Intermediate: Used in the chemical synthesis of other labeled or modified naproxen metabolites for specialized research applications.
• Toxicology Studies: Applied in research to understand the potential toxicity and reactive pathways of acyl glucuronide metabolites.

Basic Information

Product Name	(S)-Naproxen Acyl-β-D-Glucuronide Benzyl Ester
CAS No.	946517-36-8
Molecular Formula	C30H30O10
Molecular Weight	550.55 g/mol
Synonyms	Naproxen Acyl-β-D-Glucuronide Benzyl Ester; (S)-Naproxen 1-O-β-Acyl Glucuronide Benzyl Ester; Benzyl (2S)-2-(6-Methoxy-2-naphthyl)propionyl-β-D-glucopyranosiduronate; Naproxen Acyl Glucuronide Benzyl Ester; (S)-Naproxen β-1-O-Acyl Glucuronide Benzyl Ester; Benzyl Naproxen Acylglucuronide; (S)-NAP-BG; Benzyl (S)-Naproxen Glucuronide Ester
EINECS	Contact for details

Quality Control

Our (S)-Naproxen Acyl-β-D-Glucuronide Benzyl Ester is manufactured under controlled conditions to ensure the highest standards of purity and consistency, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can support compliance with relevant pharmacopeial and ICH guidelines for reference standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.