Description

Muscarinic Toxin 7 is a highly selective, high-affinity peptide toxin derived from the venom of the green mamba snake, specifically targeting the M1 subtype of muscarinic acetylcholine receptors. This compound is a critical research tool for the precise pharmacological dissection of muscarinic receptor subtypes and their signaling pathways in neurological and physiological studies. It is primarily utilized by pharmaceutical R&D teams, academic neuroscientists, and contract research organizations (CROs) engaged in neuropharmacology, receptor characterization, and drug discovery for CNS disorders.

Application

• Neuroscience Research: Selective blockade of M1 muscarinic receptors to study their role in learning, memory, and cognitive function.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening (HTS) assays for identifying novel M1 receptor modulators.
• Signal Transduction Studies: Investigation of G-protein coupled receptor (GPCR) signaling cascades specifically mediated by the M1 receptor subtype.
• Academic & Pharmaceutical R&D: Fundamental research into cholinergic systems, receptor localization, and the pathophysiology of neurological diseases such as Alzheimer's and schizophrenia.
• Biochemical Assay Development: A key component in developing and validating competitive binding assays (e.g., radioligand binding) for receptor characterization.
• Toxicology & Venom Research: Study of snake venom components and their mechanisms of action on the mammalian nervous system.

Basic Information

Item	Detail
Product Name	Muscarinic Toxin 7
CAS No.	946507-08-0
Molecular Formula	C184H282N52O55S7
Molecular Weight	~4190.8 g/mol
Synonyms	MT7; Muscarinic Toxin MT7; M1-Toxin; Dendroaspis angusticeps Toxin 7; Selective M1 Muscarinic Receptor Antagonist; α-Neurotoxin Homolog; Acetylcholine Receptor Muscarinic M1 Antagonist Peptide; M1 Receptor Antagonist Toxin
EINECS	Contact for details

Quality Control

Every batch of Muscarinic Toxin 7 is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Our quality assurance includes comprehensive analytical testing, including reversed-phase HPLC for purity assessment and mass spectrometry for identity confirmation. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, potency, and endotoxin levels, is supplied with each product to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation. Aliquot into single-use vials to minimize freeze-thaw cycles and exposure to atmospheric oxygen.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (Mass Spec)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Biological Activity (IC50)	Specified per batch on COA
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in aqueous buffers or sterile water
Protein Content	Determined by amino acid analysis

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.