Description

(1S,2R)-N,N′Bis((S)-2-Hydroxy-1-Phenylethyl)-3,3-Dimethylcyclopropane-1,2-Dicarboxamide is a high-purity, stereochemically defined chiral compound that serves as a sophisticated building block and ligand in advanced chemical synthesis. Its value lies in its rigid, functionalized cyclopropane core and dual chiral centers, which are critical for inducing stereoselectivity in catalytic reactions and constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty chemical industries who require precise chiral auxiliaries or ligands for asymmetric synthesis. The CAS number for this material is 945551-94-0.

Application

• Asymmetric Catalysis: Employed as a chiral ligand or catalyst precursor in transition metal-catalyzed reactions, such as hydrogenations, cross-couplings, and cyclopropanations.
• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system, cardiovascular, and antiviral therapies.
• Agrochemical Synthesis: Used in the development of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Chiral Resolution Agent: Functions as a resolving agent for the separation of racemic mixtures of acids or amines.
• Material Science Research: Investigated for the development of chiral polymers, liquid crystals, or advanced organic frameworks with specific optical properties.
• Academic & R&D: A valuable tool for methodological development in organic chemistry and stereochemistry research at universities and corporate R&D centers.

Basic Information

Product Name	(1S,2R)-N,N′Bis((S)-2-Hydroxy-1-Phenylethyl)-3,3-Dimethylcyclopropane-1,2-Dicarboxamide
CAS No.	945551-94-0
Molecular Formula	C30H32N2O4
Molecular Weight	484.59 g/mol
Synonyms	(1S,2R)-3,3-Dimethylcyclopropane-1,2-dicarboxylic acid bis[(S)-2-hydroxy-1-phenylethyl]amide; (1S,2R)-N,N'-Bis[(S)-2-hydroxy-1-phenylethyl]-3,3-dimethylcyclopropane-1,2-dicarboxamide; (1S,2R)-3,3-Dimethyl-N,N'-bis[(1S)-2-hydroxy-1-phenylethyl]cyclopropane-1,2-dicarboxamide; Chiral Cyclopropane Diamide Ligand; (S,S)-Hydrobenzin Derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral compound adheres to stringent quality protocols to ensure batch-to-batch consistency and stereochemical integrity. Certificates of Analysis (COA) are provided with each shipment, detailing key parameters such as chiral purity (enantiomeric excess), chemical purity, and identity confirmation. While not a bulk commodity, our quality systems are designed to support cGMP and ISO 9001 standards for advanced intermediates, ensuring traceability and reliability for your critical R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound may be hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.