Description

Boc-2,5-Dichloro-D-Phenylalanine is a protected, non-natural amino acid derivative featuring a tert-butoxycarbonyl (Boc) protecting group on the amine and chlorine substituents on the aromatic ring. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive probes, and advanced materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new drug candidates, particularly for targeted therapies.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified phenylalanine residues into peptide chains.
• Proteomics Research: Employed in the design and synthesis of enzyme inhibitors, receptor agonists/antagonists, and other bioactive peptide analogs for biochemical studies.
• Chemical Biology: Acts as a building block for creating labeled peptides or peptide-conjugates used in imaging, diagnostics, and molecular recognition.
• Material Science: Potential use in the development of specialized polymers and dendrimers with unique structural properties.

Basic Information

Product Name	Boc-2,5-Dichloro-D-Phenylalanine
CAS No.	945262-14-6
Molecular Formula	C₁₄H₁₇Cl₂NO₄
Molecular Weight	334.20 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(2,5-dichlorophenyl)propanoic acid; N-(tert-Butoxycarbonyl)-2,5-dichloro-D-phenylalanine; Boc-D-2,5-Dichlorophenylalanine; N-Boc-2,5-dichloro-D-phenylalanine; BOC-2,5-DICHLORO-D-PHE-OH; (R)-2-(Boc-amino)-3-(2,5-dichlorophenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Boc-2,5-Dichloro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.