Description

Prazosin n-β-D-Glucuronide is a high-purity reference standard and metabolite of the antihypertensive drug Prazosin. This compound is critical for pharmaceutical research and development, specifically in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by analytical laboratories, contract research organizations (CROs), and pharmaceutical companies engaged in drug discovery and regulatory compliance activities.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantification and identification of Prazosin metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used to investigate the metabolic pathways, clearance, and bioavailability of Prazosin.
• Bioanalytical Method Development: Essential for developing and validating sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring.
• Impurity Profiling: Acts as a known impurity or degradation product standard for quality control of Prazosin active pharmaceutical ingredient (API).
• Clinical Research: Employed in studies to understand patient-specific metabolic variations and drug-drug interactions involving Prazosin.
• Toxicology Studies: Used to assess metabolite-related toxicity and safety profiles in preclinical and clinical stages.

Basic Information

Product Name	Prazosin n-β-D-Glucuronide
CAS No.	944943-73-1
Molecular Formula	C23H29N5O9
Molecular Weight	519.51 g/mol
Synonyms	Prazosin N-Glucuronide; Prazosin Glucuronide; Prazosin β-D-Glucuronide; 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine β-D-Glucopyranosiduronic Acid; Furazosin Glucuronide; Prazosin Metabolite; Prazosin N-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Prazosin n-β-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical reference standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.