Description

Oxazole, 4-Cyclohexyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-, (4R)- is a specialized chiral organophosphorus-oxazole hybrid ligand. This compound matters for its critical role in facilitating highly selective transition metal-catalyzed reactions, enabling the synthesis of complex, enantiomerically pure molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for asymmetric synthesis, particularly in hydrogenation and cross-coupling applications.

Application

• As a chiral ligand in asymmetric hydrogenation catalysts for pharmaceutical intermediates.
• For enantioselective C-C and C-X bond-forming cross-coupling reactions.
• In the development of novel transition metal complexes for catalytic research.
• As a key building block or auxiliary ligand in the synthesis of active pharmaceutical ingredients (APIs).
• For academic and industrial R&D in stereoselective organic synthesis.
• In the preparation of fine chemicals and specialty materials requiring high optical purity.

Basic Information

Product Name	Oxazole, 4-Cyclohexyl-2-[2-(Diphenylphosphino)Phenyl]-4,5-Dihydro-, (4R)-
CAS No.	944836-02-6
Molecular Formula	C33H34NOP
Molecular Weight	491.60 g/mol
Synonyms	(4R)-4-Cyclohexyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (R)-4-Cyclohexyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole; (R)-Cyclohexyl-PHOX; (R)-Cy-PHOX; (R)-4-Cyclohexyl-PHOX; (R)-2-[2-(Diphenylphosphino)phenyl]-4-cyclohexyl-4,5-dihydrooxazole; PHOX Ligand derivative; Chiral Dihydrooxazole Phosphine Ligand
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing specifications such as assay, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C). This compound is easily oxidized and light-sensitive; prolonged exposure to air or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.