Description

2-Trifluoromethyl-5-Bromoanisole is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. This compound matters because its unique trifluoromethyl and bromo substituents make it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group often contributes to improved efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis, enabling novel reaction pathways.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl and other complex structures.
• Fluorine Chemistry Studies: An important compound for research into the effects of fluorine substitution on aromatic system reactivity and physical properties.

Basic Information

Product Name	2-Trifluoromethyl-5-Bromoanisole
CAS No.	944805-63-4
Molecular Formula	C8H6BrF3O
Molecular Weight	255.04 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)anisole; 1-Bromo-4-methoxy-2-(trifluoromethyl)benzene; 2-Bromo-5-methoxybenzotrifluoride; 3-Bromo-6-methoxy-α,α,α-trifluorotoluene; 5-Bromo-α,α,α-trifluoro-o-anisole; 2-Trifluoromethyl-5-bromo-1-methoxybenzene; Anisole, 5-bromo-2-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-5-Bromoanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurities, and physical characteristics are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.