Description

2-Fluoro-5-(Methoxycarbonylmethyl)Phenylboronic Acid,Pinacol Ester is a high-purity, synthetically valuable organoboron reagent. This compound is a critical building block in modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl and heterobiaryl scaffolds found in drug candidates.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where fluorination modulates electronic properties.
• Chemical Biology Probes: Utilized to create tagged molecules for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and non-commercial quantities for research.

Basic Information

Product Name	2-Fluoro-5-(Methoxycarbonylmethyl)Phenylboronic Acid,Pinacol Ester
CAS No.	944317-66-2
Molecular Formula	C15H20BFO4
Molecular Weight	294.13 g/mol
Synonyms	[2-Fluoro-5-(2-methoxy-2-oxoethyl)phenyl]boronic acid pinacol ester; 2-(3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetic acid methyl ester; Methyl 2-[3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetate; 2-Fluoro-5-(methoxycarbonylmethyl)benzeneboronic acid pinacol ester; Boronic acid, B-[2-fluoro-5-[(methoxycarbonyl)methyl]phenyl]-, 1,1-dimethylethyl ester (9CI); 944317-66-2 (CAS); Fluorophenylboronic ester acetic acid methyl ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(Methoxycarbonylmethyl)Phenylboronic Acid,Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems support compliance with global regulatory requirements for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.