Description

4-Chloro-2-Fluoro-3-Methoxyphenylboronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. Its core value lies in its role as a key building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the chloro-fluoro-methoxy substitution pattern imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organoboron catalysts used in asymmetric synthesis and other advanced catalytic processes.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors, where precise molecular structure controls material properties.
• Chemical Biology Probes: Utilized in the construction of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis and Contract Manufacturing: A vital component for CROs and CDMOs offering bespoke chemical synthesis services to global clients.

Basic Information

Product Name	4-Chloro-2-Fluoro-3-Methoxyphenylboronic Acid
CAS No.	944129-07-1
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	(4-Chloro-2-fluoro-3-methoxyphenyl)boronic acid; 2-Fluoro-4-chloro-3-methoxybenzeneboronic acid; 4-Chloro-2-fluoro-3-methoxybenzeneboronic acid; Boronic acid, B-(4-chloro-2-fluoro-3-methoxyphenyl)-; 944129-07-1; 4-Chloro-2-fluoro-3-methoxy phenylboronic acid; 3-Methoxy-4-chloro-2-fluorophenylboronic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoro-3-Methoxyphenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality parameters. Our commitment to quality supports compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.