Description

H-D-Arg(Pbf)-Allyl Ester Hcl is a protected arginine derivative, specifically an allyl ester of NG-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl (Pbf)-protected D-arginine hydrochloride salt. This compound is a critical building block (Fmoc/Boc-SPPS intermediate) for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and CDMOs engaged in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key, protected D-arginine derivative for the controlled incorporation of the D-arginine residue into peptide chains using Fmoc or Boc chemistry.
• Pharmaceutical Research: Synthesis of novel therapeutic peptides targeting GPCRs, enzymes, and other biological pathways where D-amino acids enhance metabolic stability.
• Peptidomimetic Development: Building block for creating modified peptide structures with improved pharmacological properties, such as enhanced bioavailability and receptor selectivity.
• Bioconjugation & Probe Synthesis: Intermediate for preparing peptide-based imaging probes, affinity labels, or drug conjugates, leveraging the allyl ester for selective deprotection.
• Academic & Institutional Research: Used in biochemical and structural biology studies to investigate protein-protein interactions and enzyme mechanisms.
• Contract Manufacturing: Essential raw material for CDMOs and fine chemical suppliers producing custom peptides at gram to kilogram scale for clinical trials.

Basic Information

Item	Details
Product Name	H-D-Arg(Pbf)-Allyl Ester Hcl
CAS No.	943986-60-5
Molecular Formula	C22H35N5O6S · HCl
Molecular Weight	534.07 g/mol
Synonyms	D-Arg(Pbf)-OAll · HCl; H-D-Arg(Pbf)-OAll · HCl; Allyl NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-D-argininate hydrochloride; D-Arginine, NG-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-, allyl ester, hydrochloride; (2R)-5-[[(2,2,4,6,7-Pentamethyldihydrobenzofuran-5-yl)sulfonyl]amino]-2-(prop-2-en-1-yloxycarbonylamino)pentanoic acid prop-2-en-1-yl ester hydrochloride
EINECS	Contact for details

Quality Control

Our H-D-Arg(Pbf)-Allyl Ester Hcl is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity and consistent stereochemical integrity, critical for sensitive peptide synthesis applications. Certificates of Analysis (COA) providing full HPLC purity, chiral purity, and identity confirmation are available upon request. We support compliance needs for cGMP and ISO standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent decomposition. For long-term storage (over 12 months), consider storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.