Description

Methyl (2R)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate is a high-purity, chiral amino acid derivative extensively used as a critical building block in advanced organic synthesis. Its value lies in providing a protected glutamic acid side chain precursor, essential for constructing complex peptide-based molecules with precise stereochemistry. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including protease inhibitors and other bioactive peptides. CAS number 943975-78-8.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of peptide-based drug candidates and active pharmaceutical ingredients (APIs).
• Protease Inhibitor Research: Used in the design and development of inhibitors targeting specific enzymes like glutamic acid proteases.
• Peptide Chemistry: Serves as a protected glutamic acid analog for solid-phase and solution-phase peptide synthesis (SPPS).
• Chemical Biology: Employed in the creation of labeled peptides and molecular probes for studying biological mechanisms.
• Asymmetric Synthesis: Utilized as a starting material for the preparation of other non-proteinogenic amino acids and chiral auxiliaries.
• Academic & Industrial R&D: Fundamental building block for exploratory research in medicinal chemistry and organic synthesis.

Basic Information

Product Name	Methyl (2R)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate
CAS No.	943975-78-8
Molecular Formula	C17H29NO7
Molecular Weight	359.42 g/mol
Synonyms	Methyl (R)-2-((Boc)2N)-5-oxopentanoate; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-5-oxopentanoate; (2R)-2-[(2-Methylpropan-2-yl)oxycarbonylamino]-5-oxopentanoic acid methyl ester; Boc-Glu(OMe)-OH (protected derivative); Methyl 2-(N,N-di-Boc-amino)-5-oxopentanoate; (R)-2-(Di-tert-butoxycarbonylamino)-5-oxopentanoic acid methyl ester; Glutamic acid derivative, N-Boc protected methyl ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Methyl (2R)-2-(Bis(tert-Butoxycarbonyl)Amino)-5-Oxopentanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and pre-clinical applications. We employ advanced analytical techniques including HPLC, NMR, and chiral analysis to verify identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light) and should be handled with care in environments using strong acid/organic solvent. For long-term storage, consider inert atmosphere conditions to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.