Description

(2-Chloro-4-Fluoro-3-Methoxyphenyl)Boronic Acid is a high-purity, multi-functional boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily utilized by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging its halogen and methoxy substituents for bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as polymers for OLEDs and sensors, where its structure allows for fine-tuning of electronic properties.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors, capitalizing on boronic acid's affinity for diols.
• Catalyst & Ligand Development: Serves as a starting material for synthesizing novel boron-containing catalysts and ligands used in asymmetric synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and small-scale API (Active Pharmaceutical Ingredient) batches.

Basic Information

Product Name	(2-Chloro-4-Fluoro-3-Methoxyphenyl)Boronic Acid
CAS No.	943831-11-6
Molecular Formula	C7H7BClFO3
Molecular Weight	203.39 g/mol
Synonyms	2-Chloro-4-fluoro-3-methoxybenzeneboronic acid; (2-Chloro-4-fluoro-3-methoxyphenyl)boronic acid; B-(2-Chloro-4-fluoro-3-methoxyphenyl)boronic acid; 3-Methoxy-2-chloro-4-fluorophenylboronic acid; 2-Chloro-4-fluoro-3-methoxybenzeneboronic acid pinacol ester (protected form); 943831-11-6; (2-Cl-4-F-3-MeO-Ph)B(OH)2
EINECS	Contact for details

Quality Control

Our (2-Chloro-4-Fluoro-3-Methoxyphenyl)Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete chromatographic data are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.