Description

1-Bromo-2,4-Difluoro-5-Methoxybenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and manufacturers developing active pharmaceutical ingredients (APIs), liquid crystal materials, and specialty agrochemicals where precise fluorination and functionalization are required.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the difluoro-methoxybenzene core contributes to biological activity and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies (LCDs).
• Organic Light-Emitting Diodes (OLEDs): Employed in the development of electron-transport materials and host materials for OLED devices.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to create biaryl structures.
• Material Science Research: Used in the development of novel polymers and advanced organic frameworks with specific electronic properties.

Basic Information

Product Name	1-Bromo-2,4-Difluoro-5-Methoxybenzene
CAS No.	943831-06-9
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	2,4-Difluoro-5-methoxybromobenzene; 5-Bromo-2,4-difluoroanisole; 1-Bromo-2,4-difluoro-5-methoxy-benzene; Benzene, 1-bromo-2,4-difluoro-5-methoxy-; 2-Bromo-1,3-difluoro-4-methoxybenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,4-Difluoro-5-Methoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.