Description

1-Bromo-4-Chloro-2-Fluoro-3-Isopropoxybenzene is a high-purity, multi-substituted benzene derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its precise halogen and ether substitution pattern makes it a valuable building block for constructing complex molecules with specific electronic and steric properties. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the halogen and alkoxy groups contribute to bioactivity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated aromatic cores for electronic materials used in displays and organic light-emitting diodes.
• Polymer Chemistry: Acts as a monomer or functionalization agent for creating specialty polymers with enhanced thermal stability and specific chemical resistance.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, enabling rapid diversification of chemical libraries.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodological studies and as a benchmark compound in process chemistry optimization.

Basic Information

Product Name	1-Bromo-4-Chloro-2-Fluoro-3-Isopropoxybenzene
CAS No.	943830-17-9
Molecular Formula	C9H9BrClFO
Molecular Weight	267.52 g/mol
Synonyms	3-Bromo-6-Chloro-2-Fluoroanisole, Isopropoxy; 2-Fluoro-3-isopropoxy-1-bromo-4-chlorobenzene; 1-Bromo-4-chloro-2-fluoro-3-(1-methylethoxy)benzene; Benzene, 1-bromo-4-chloro-2-fluoro-3-(1-methylethoxy)-; 4-Chloro-2-fluoro-3-isopropoxy-1-bromobenzene; 943830-17-9; BCFIPB (abbreviation)
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Chloro-2-Fluoro-3-Isopropoxybenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliable consistency and traceability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.