Description

n-Boc-4-(1,3-Dioxolan-2-Yl)Aniline is a protected aniline derivative featuring both a tert-butoxycarbonyl (Boc) amine protecting group and a 1,3-dioxolane acetal functionality. This dual-protected intermediate is of critical importance in multi-step organic synthesis, particularly in pharmaceutical research and development, where it enables the selective manipulation of reactive amine groups. It is primarily utilized by medicinal chemists and process development scientists in the synthesis of complex bioactive molecules, including active pharmaceutical ingredients (APIs) and advanced agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those requiring sequential deprotection strategies.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that incorporate aniline-derived structures.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers and functional organic materials.
• Academic & R&D Laboratories: Employed in methodological studies and the discovery of new synthetic routes involving protected aromatic amines.
• Peptide Mimetics: Useful in the construction of non-natural amino acid derivatives and peptide analogs for biochemical studies.

Basic Information

Product Name	n-Boc-4-(1,3-Dioxolan-2-Yl)Aniline
CAS No.	943780-61-8
Molecular Formula	C14H19NO4
Molecular Weight	265.31 g/mol
Synonyms	tert-Butyl N-[4-(1,3-dioxolan-2-yl)phenyl]carbamate; 4-(1,3-Dioxolan-2-yl)aniline, N-Boc-protected; 1-Boc-amino-4-(1,3-dioxolan-2-yl)benzene; 4-(2,2-Dimethyl-1,3-dioxolan-4-yl)aniline, Boc derivative; Carbamic acid, N-[4-(1,3-dioxolan-2-yl)phenyl]-, 1,1-dimethylethyl ester; Boc-4-(1,3-dioxolan-2-yl)aniline; 943780-61-8; N-Boc-4-(2,2-dimethyl-1,3-dioxolan-4-yl)aniline (common misnomer)
EINECS	Contact for details

Quality Control

Our n-Boc-4-(1,3-Dioxolan-2-Yl)Aniline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.