Description

Propargyl-Peg3-Ms is a specialized bifunctional linker molecule featuring a propargyl group and a mesylate (Ms) leaving group, connected by a triethylene glycol (PEG3) spacer. This compound is a critical reagent in click chemistry and bioconjugation strategies, enabling the efficient and selective modification of biomolecules, polymers, and surfaces. It is primarily utilized by researchers and process developers in the pharmaceutical, biotechnology, and materials science industries for applications such as drug discovery, proteomics, and the development of advanced polymeric materials.

Application

• Bioconjugation and Click Chemistry: Acts as a key reagent for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions to label proteins, peptides, antibodies, and oligonucleotides.
• Polymer Functionalization: Used to introduce propargyl handles into polymer backbones or dendrimers for subsequent cross-linking or attachment of functional moieties.
• Surface Modification: Enables the functionalization of nanoparticles, microarrays, and solid supports for biosensing and diagnostic applications.
• Prodrug Synthesis: Serves as a versatile linker in the design and synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutic agents.
• Chemical Biology Probes: Facilitates the creation of activity-based probes for studying enzyme function and protein-protein interactions.
• Materials Science: Employed in the development of hydrogels, smart materials, and functional coatings with tailored properties.

Basic Information

Product Name	Propargyl-Peg3-Ms
CAS No.	943726-01-0
Molecular Formula	C13H24O7S
Molecular Weight	324.39 g/mol
Synonyms	1-(2-(2-(2-(Prop-2-yn-1-yloxy)ethoxy)ethoxy)ethyl methanesulfonate; Propargyl-PEG3-mesylate; Propargyl-O-triethylene glycol mesylate; 2,5,8,11-Tetraoxatetradec-13-yn-14-yl methanesulfonate; Propargyl PEG3 mesylate ester; Propargyl-PEG3-OMs; mPEG3-Propargyl Mesylate
EINECS	Contact for details

Quality Control

Our Propargyl-Peg3-Ms is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and KF titration for moisture content, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.