Description

Ethynyl-Cyclopropan is a specialized organic building block featuring a reactive ethynyl group attached to a strained cyclopropane ring. This unique molecular architecture makes it a valuable intermediate for synthesizing complex molecules in advanced research and development. It is particularly sought after by pharmaceutical, agrochemical, and material science industries for constructing novel compounds with specific three-dimensional properties. The compound is supplied under strict quality control to ensure consistency for critical synthetic applications.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting cyclopropane-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the cyclopropane moiety can enhance biological activity.
• Material Science Research: Serves as a precursor for novel polymers, dendrimers, or metal-organic frameworks (MOFs) requiring rigid, angled building blocks.
• Organic Synthesis & Catalysis: A versatile reagent for [2+2] cycloadditions, cross-coupling reactions, and other transformations to create complex, strained-ring systems.
• Ligand & Catalyst Development: The ethynyl group allows for functionalization to create specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Used to incorporate a bio-orthogonal alkyne handle into molecules for labeling and studying biological systems via click chemistry.

Basic Information

Product Name	Ethynyl-Cyclopropan
CAS No.	336800-75-0
Molecular Formula	C5H6
Molecular Weight	66.10 g/mol
Synonyms	Ethynylcyclopropane; Cyclopropylacetylene; 1-Cyclopropylethyne; 1-Ethynylcyclopropane; Cyclopropane, ethynyl-; 1-Cyclopropyl-1-ethyne; 1-Cyclopropylethyne; 1-Ethynyl-cyclopropane
EINECS	Contact for details

Quality Control

Our Ethynyl-Cyclopropan is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure high purity and batch-to-batch consistency. Quality is verified against established internal specifications using advanced techniques including GC, GC-MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, ideally at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. Containers should be kept tightly sealed when not in use to prevent evaporation and potential contamination.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.