Description

5-(4-Ethynylphenyl)-1,3-Oxazole is a high-purity, specialized heterocyclic building block featuring a conjugated oxazole core and a terminal ethynyl group. This unique molecular architecture makes it a valuable intermediate for constructing advanced materials and complex organic molecules. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors for applications in drug discovery, ligand synthesis, and the development of functional polymers.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the creation of new crop protection agents and herbicides, leveraging its heterocyclic structure for bioactivity.
• Materials Science Research: Acts as a monomer or cross-linking agent in the synthesis of conjugated polymers and organic electronic materials for OLEDs or sensors.
• Chemical Biology & Proteomics: Employed as a click chemistry handle (via the alkyne group) for bioconjugation, labeling biomolecules, or developing chemical probes.
• Ligand & Catalyst Development: Utilized in organometallic chemistry to create novel ligands for catalysis or metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A versatile building block for synthetic organic chemistry research across multiple disciplines.

Basic Information

Product Name	5-(4-Ethynylphenyl)-1,3-Oxazole
CAS No.	501944-63-4
Molecular Formula	C11H7NO
Molecular Weight	169.18 g/mol
Synonyms	4-(1,3-Oxazol-5-yl)phenylacetylene; 5-(4-Ethynylphenyl)oxazole; 1,3-Oxazole, 5-(4-ethynylphenyl)-; 4-(Oxazol-5-yl)phenylacetylene; 5-(p-Ethynylphenyl)oxazole; 4-(5-Oxazolyl)phenylacetylene
EINECS	Contact for details

Quality Control

Our 5-(4-Ethynylphenyl)-1,3-Oxazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with all shipments, detailing the exact specifications for your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.