Description

Figitumumab is a fully human monoclonal antibody targeting the insulin-like growth factor 1 receptor (IGF-1R). This compound is a critical research tool and therapeutic candidate for investigating pathways involved in cell proliferation and survival. It is primarily utilized by pharmaceutical researchers and biotechnology companies focused on oncology and metabolic disorders. The product, identified as CAS NO 943453-46-1, is supplied under stringent quality controls to ensure reliability for advanced biomedical applications.

Application

• Oncology Research: Investigation of IGF-1R signaling pathways in various cancer models, including lung, breast, and prostate cancers.
• Preclinical Drug Development: Used as a reference standard or active pharmaceutical ingredient (API) in the development of targeted cancer therapies.
• Biomarker Studies: Tool for validating IGF-1R as a biomarker in patient stratification and companion diagnostic development.
• Mechanistic Studies: Research into the role of IGF-1R in cell growth, differentiation, and apoptosis (programmed cell death).
• Antibody Engineering: Serves as a model molecule for studying human monoclonal antibody structure, function, and optimization.
• In vitro & In vivo Assays: Critical reagent in cell-based assays and animal studies to evaluate therapeutic efficacy and safety profiles.

Basic Information

Product Name	Figitumumab
CAS No.	943453-46-1
Molecular Formula	C6440H9916N1704O2016S46
Molecular Weight	Approx. 145 kDa
Synonyms	CP-751,871; Anti-IGF-1R Recombinant Monoclonal Antibody; IGF-1R Inhibitor CP-751871; Fully Human Anti-IGF1R IgG2 Monoclonal Antibody; NSC 753128; UNII-1V862U96BN; Anti-IGF1 Receptor Antibody
EINECS	Contact for details

Quality Control

Our Figitumumab is manufactured and tested under strict quality systems to ensure it meets the high standards required for research and development. Each batch is characterized for identity, purity, potency, and stability. A comprehensive Certificate of Analysis (COA) is provided, detailing results from tests including SDS-PAGE, size-exclusion HPLC (SE-HPLC), endotoxin levels, and binding affinity assays. We adhere to relevant portions of cGMP guidelines for the production of biopharmaceutical research materials.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted and stored at -80°C to minimize freeze-thaw cycles. This product is easily oxidized; store under inert atmosphere when applicable and use immediately after preparation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Consistent with reference standard
Purity (SE-HPLC)	≥ 95% (Monomer)
Protein Content (UV Absorbance)	≥ 1.0 mg/vial
Endotoxin	< 1.0 EU/mg
Binding Activity (ELISA/SPR)	Meets internal reference standard
Sterility (for sterile-filtered lots)	Sterile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.