Description

5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is a high-value, multi-functional organic building block that serves as a critical intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of a reactive benzaldehyde group and a protected boronic acid (pinacol boronate ester), enabling efficient cross-coupling reactions and subsequent functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel fluorinated drug candidates, including kinase inhibitors and active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used to construct complex, fluorinated heterocycles that are core structures in modern herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of fluorine.
• Ligand & Catalyst Development: Serves as a starting material for creating sophisticated bidentate ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Functional Material Research: Employed in the synthesis of organic electronic materials, such as fluorinated polymers and small molecules for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Chemical Biology Probes: Utilized to create fluorophore-labeled boronic acid probes for sensing and imaging applications, including glucose sensing.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D pipelines.

Basic Information

Product Name	5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde
CAS No.	943310-52-9
Molecular Formula	C13H16BFO3
Molecular Weight	250.08 g/mol
Synonyms	2-Formyl-4-fluorophenylboronic acid pinacol ester; (5-Fluoro-2-formylphenyl)boronic acid pinacol ester; 5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 4-Fluoro-2-(pinacolatoboryl)benzaldehyde; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-fluorobenzaldehyde; 5-Fluoro-2-formylbenzeneboronic acid pinacol ester; 943310-52-9
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Benzaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.