Description

L-Proline, n-[(1,1-Dimethylethoxy)Carbonyl]Glycyl-4-(Benzoylamino)-, Methyl Ester, (4R)- is a sophisticated, chirally pure protected dipeptide derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex peptide sequences and peptidomimetics, where the Boc-protected glycine and benzoylated proline moieties offer orthogonal protection strategies. This high-purity intermediate is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic agents, prodrugs, and bioactive compounds. The compound's defined stereochemistry at the 4R position ensures consistent and predictable outcomes in stereoselective reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex peptide-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Peptidomimetic Research: Used to design and synthesize non-peptide molecules that mimic the structure and function of natural peptides for enhanced stability and bioavailability.
• Solid-Phase Peptide Synthesis (SPPS): Serves as a protected amino acid derivative for the sequential assembly of custom peptide sequences on resin.
• Prodrug Development: Utilized in creating prodrug forms where the ester and protecting groups are strategically cleaved to release the active drug molecule.
• Bioconjugation Chemistry: Acts as a linker or spacer molecule in the conjugation of peptides to other biomolecules, polymers, or surfaces.
• Chemical Biology Probes: Incorporated into tool compounds for studying enzyme mechanisms, protein-protein interactions, and cellular pathways.
• Agrochemical Research: Potential intermediate in the development of novel peptide-inspired crop protection agents.

Basic Information

Item	Details
Product Name	L-Proline, n-[(1,1-Dimethylethoxy)Carbonyl]Glycyl-4-(Benzoylamino)-, Methyl Ester, (4R)-
CAS No.	943134-40-5
Molecular Formula	C21H29N3O6
Molecular Weight	419.47 g/mol
Synonyms	(4R)-N-[(tert-Butoxycarbonyl)glycyl]-4-(benzoylamino)-L-proline methyl ester; Boc-Gly-(4-Bz-NH)-L-Pro-OMe; Boc-Gly-4-(Benzoylamino)-L-Pro-OMe; N-Boc-glycyl-4-(benzamido)-L-proline methyl ester; tert-Butyl N-[2-[[(4R)-4-benzamido-1-methoxy-1-oxopentan-2-yl]amino]-2-oxoethyl]carbamate; Protected dipeptide derivative; Boc-Gly-4-BzNH-Pro-OMe
EINECS	Contact for details

Quality Control

Our production of this advanced synthetic intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical research and development. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We support compliance with cGMP guidelines for pharmaceutical applications, and custom purity grades (e.g., >98%, >99%) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage (over 12 months), consider storage at 2-8°C under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee (4R)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.