Description

(S)-5,7-Difluorochroman-4-Ol is a chiral fluorinated chroman derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block for the development of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of new therapeutic agents, particularly those targeting central nervous system and metabolic disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potential drug candidates, especially serotonin and dopamine receptor modulators.
• Asymmetric Synthesis Building Block: Utilized in the construction of complex, enantiomerically pure molecules due to its defined (S)-configuration.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes for Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Used as an analytical standard for method development and quality control in chiral analysis.

Basic Information

Product Name	(S)-5,7-Difluorochroman-4-Ol
CAS No.	942195-91-7
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	(4S)-5,7-Difluoro-3,4-dihydro-2H-1-benzopyran-4-ol; (S)-5,7-Difluoro-4-chromanol; (S)-5,7-Difluoro-3,4-dihydro-2H-chromen-4-ol; 5,7-Difluorochroman-4-ol, (S)-; (S)-4-Chromanol, 5,7-difluoro-; (S)-5,7-Difluorochroman-4-ol; (4S)-5,7-Difluorochroman-4-ol
EINECS	Contact for details

Quality Control

Our (S)-5,7-Difluorochroman-4-Ol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, and chiral excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.