Description

4-Fmoc-3(R)-Morpholinecarboxylic Acid is a high-purity, non-natural amino acid derivative featuring a protected carboxylic acid group and an Fmoc-protected amine, making it a crucial chiral building block. This compound is specifically engineered for the synthesis of complex, stereochemically defined molecules, offering precise control over molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced peptide synthesis, medicinal chemistry, and the development of novel drug candidates and bioactive compounds.

Application

• Peptide Synthesis: A key chiral intermediate for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics.
• Medicinal Chemistry: Used in the research and development of new pharmaceutical agents, particularly for creating constrained scaffolds and probing structure-activity relationships (SAR).
• Chemical Biology: Employed in the synthesis of labeled probes, enzyme inhibitors, and other tools for studying biological processes.
• Combinatorial Chemistry: Serves as a valuable building block in libraries for high-throughput screening to identify new lead compounds.
• API Intermediate: Acts as a sophisticated precursor in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) requiring specific stereochemistry.
• Academic Research: Utilized in university and institutional labs for methodological development in organic synthesis and asymmetric catalysis.

Basic Information

Product Name	4-Fmoc-3(R)-Morpholinecarboxylic Acid
CAS No.	942153-03-9
Molecular Formula	C21H21NO5
Molecular Weight	367.40 g/mol
Synonyms	Fmoc-3(R)-Morpholine-4-carboxylic Acid; (R)-4-((((9H-Fluoren-9-yl)methoxy)carbonyl)morpholine-3-carboxylic Acid; 3(R)-Morpholinecarboxylic Acid, 4-(9-Fluorenylmethoxycarbonyl)-; 4-Fmoc-morpholine-3(R)-carboxylic Acid; (R)-4-(Fmoc-amino)-tetrahydro-2H-1,4-oxazine-3-carboxylic Acid; 4-N-Fmoc-3(R)-morpholinecarboxylic Acid; Fmoc-D-Mor(3-COOH)-OH; 942153-03-9
EINECS	Contact for details

Quality Control

Our 4-Fmoc-3(R)-Morpholinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR for structural confirmation. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.