Description

Methyl-4-Hydroxy-2-Methyl-D3-2H-1,2-Benzothiazine-3-Carboxylate 1,1-Dioxide is a high-purity, deuterium-labeled isotopologue of a key benzothiazine derivative. This compound is critically important as a stable isotope-labeled internal standard for quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical measurements. It is primarily needed by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical testing facilities engaged in drug metabolism and pharmacokinetics (DMPK) studies, bioanalytical method development, and impurity profiling.

Application

• Internal Standard for LC-MS/MS: Serves as a critical reference compound for the precise quantification of its non-deuterated counterpart and related metabolites in complex biological matrices like plasma, serum, and urine.
• Drug Metabolism Studies (DMPK): Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) by providing a non-interfering isotopic marker for mass spectrometric detection.
• Bioanalytical Method Development: Used to validate and optimize liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for pharmaceutical compounds, improving method robustness and regulatory compliance.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Research: Facilitates reliable concentration-time profiling of active pharmaceutical ingredients (APIs) and their metabolites in preclinical and clinical trials.
• Impurity and Degradant Analysis: Aids in the identification and quantification of process-related impurities and degradation products during API development and quality control.
• Stable Isotope Labeling Studies: Employed in mechanistic studies to elucidate metabolic pathways and biotransformation mechanisms of benzothiazine-based drug candidates.

Basic Information

Product Name	Methyl-4-Hydroxy-2-Methyl-D3-2H-1,2-Benzothiazine-3-Carboxylate 1,1-Dioxide
CAS No.	942047-62-3
Molecular Formula	C11H8D3NO5S
Molecular Weight	268.29 g/mol (approx.)
Synonyms	Methyl 4-hydroxy-2-(methyl-d3)-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxide; Deuterated Piroxicam Methyl Ester (d3); Piroxicam Methyl Ester-d3; 4-Hydroxy-2-methyl-d3-2H-1,2-benzothiazine-3-carboxylic Acid Methyl Ester 1,1-Dioxide; Methyl 2-(Methyl-d3)-4-oxido-1,1-dioxo-1,2-benzothiazine-3-carboxylate; CAS 942047-62-3; Benzothiazine-d3 Carboxylate Derivative
EINECS	Contact for details

Quality Control

Our deuterated standards are manufactured under strict quality control protocols to ensure the highest isotopic purity and chemical integrity. Each batch is characterized using advanced analytical techniques including NMR, HPLC, and high-resolution mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing parameters such as chemical purity, isotopic enrichment (D3), and chromatographic profile. We support compliance with ICH Q2(R1) guidelines for analytical method validation.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.