Description

5-[2-(Bromomethyl)Phenyl]-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole is a high-value, multi-functional organic intermediate characterized by its bromomethyl and trifluoromethyl functional groups. This compound is essential for synthetic chemists developing novel active pharmaceutical ingredients (APIs) and advanced agrochemicals, where its unique structure enables critical carbon-carbon bond formation and the introduction of lipophilic motifs. It is primarily sought after by R&D and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers due to its aromatic and halogenated structure.
• Cross-Coupling Reactions: The bromomethyl moiety makes it a valuable electrophile in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Fluorine Chemistry: Acts as a versatile scaffold for introducing fluorine-containing groups into target molecules, a critical strategy in modern medicinal chemistry.

Basic Information

Product Name	5-[2-(Bromomethyl)Phenyl]-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole
CAS No.	941716-87-6
Molecular Formula	C12H10BrF3N2
Molecular Weight	319.12 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-5-[2-(bromomethyl)phenyl]-1H-pyrazole; 5-(2-Bromobenzyl)-1-methyl-3-(trifluoromethyl)pyrazole; 1-Methyl-5-(2-bromobenzyl)-3-(trifluoromethyl)-1H-pyrazole; 5-(2-Bromomethylphenyl)-1-methyl-3-trifluoromethylpyrazole; 941716-87-6; Pyrazole derivative, 5-[2-(bromomethyl)phenyl]-1-methyl-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our production of 5-[2-(Bromomethyl)Phenyl]-1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. Quality is verified through advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting cGMP-compliant development workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.