Description

1-Boc-4-(2,4-Difluorophenyl)-4-Hydroxypiperidine is a high-value, protected piperidine derivative that serves as a critical synthetic intermediate in modern organic chemistry. Its primary value lies in its role as a versatile building block for constructing complex molecules, particularly in the pharmaceutical sector. This compound is essential for research chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and advanced material science.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, leveraging its difluorophenyl moiety for bioactivity.
• Chemical Synthesis Scaffold: Serves as a protected precursor for introducing the 4-(2,4-difluorophenyl)-4-hydroxypiperidine moiety into more complex molecular architectures.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of fine chemicals.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	1-Boc-4-(2,4-Difluorophenyl)-4-Hydroxypiperidine
CAS No.	941711-19-9
Molecular Formula	C16H21F2NO3
Molecular Weight	313.34 g/mol
Synonyms	1-Boc-4-(2,4-difluorophenyl)-4-hydroxypiperidine; tert-Butyl 4-(2,4-difluorophenyl)-4-hydroxypiperidine-1-carboxylate; 4-(2,4-Difluorophenyl)-4-hydroxy-1-piperidinecarboxylic acid 1,1-dimethylethyl ester; 4-(2,4-Difluorophenyl)-4-hydroxypiperidine-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-4-(2,4-difluorophenyl)-4-hydroxypiperidine; 1-Boc-4-(2,4-DFP)-4-hydroxypiperidine; 941711-19-9
EINECS	Contact for details

Quality Control

Our 1-Boc-4-(2,4-Difluorophenyl)-4-Hydroxypiperidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.