Description

1-(Benzyloxy)-4-Bromo-2,3-Difluorobenzene is a high-purity, multi-functional aromatic building block designed for advanced organic synthesis. This compound is valued for its unique substitution pattern, which provides strategic handles for selective cross-coupling and nucleophilic aromatic substitution reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, including active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the difluoro and bromo substituents for bioactivity.
• Material Science Precursor: Serves as a monomer or intermediate in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed reactions like Suzuki, Negishi, or Stille couplings to introduce complex aryl groups.
• Nucleophilic Aromatic Substitution (SNAr): The activated difluoro aromatic system allows for selective displacement with various nucleophiles, enabling rapid diversification.
• Chemical Research & Development: An essential reagent in academic and industrial labs for methodological studies and the exploration of new synthetic pathways.

Basic Information

Product Name	1-(Benzyloxy)-4-Bromo-2,3-Difluorobenzene
CAS No.	941294-52-6
Molecular Formula	C13H9BrF2O
Molecular Weight	299.11 g/mol
Synonyms	4-Bromo-2,3-difluorophenyl benzyl ether; Benzyl 4-bromo-2,3-difluorophenyl ether; 1-Bromo-4-(benzyloxy)-2,3-difluorobenzene; 2,3-Difluoro-4-bromophenyl benzyl ether; 4-Bromo-1-(benzyloxy)-2,3-difluorobenzene; 1-(Benzyloxy)-4-bromo-2,3-difluorobenzene; BDFB (abbreviation).
EINECS	Contact for details

Quality Control

Every batch of 1-(Benzyloxy)-4-Bromo-2,3-Difluorobenzene is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and advanced intermediates. Comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.