Description

Docetaxel-D9 is a deuterium-labeled analog of the potent anticancer agent Docetaxel, specifically designed for use as an internal standard in quantitative bioanalytical studies. This high-purity stable isotope-labeled compound is essential for ensuring the accuracy and reliability of pharmacokinetic and metabolic research. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced oncology drug development and analytical method validation.

Application

• Internal Standard for LC-MS/MS: Serves as a critical internal standard in Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) assays for the precise quantification of Docetaxel in biological matrices such as plasma, serum, and tissue homogenates.
• Pharmacokinetic & Metabolism Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion (ADME) profiles in preclinical and clinical research.
• Bioanalytical Method Development & Validation: Used to develop, optimize, and validate robust analytical methods compliant with FDA, EMA, and ICH guidelines.
• Drug-Drug Interaction Studies: Facilitates research into potential metabolic interactions between Docetaxel and other co-administered pharmaceuticals.
• Quality Control in Manufacturing: Can be employed in quality control laboratories to monitor process-related impurities or for assay standardization.

Basic Information

Product Name	Docetaxel-D9
CAS No.	940867-25-4
Molecular Formula	C43H49D9NO14
Molecular Weight	830.91 g/mol (approximate)
Synonyms	Deuterated Docetaxel; Docetaxel (phenyl-d5, 3',5'-d4); (2R,3S)-N-Carboxy-3-phenylisoserine, N-tert-butyl ester, 13-ester with 5β,20-epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4-acetate 2-benzoate, phenyl-d5, 3',5'-d4-; Taxotere-D9; NSC 628503-D9
EINECS	Contact for details

Quality Control

Our Docetaxel-D9 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for the most demanding analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D9), chemical purity (by HPLC), and identification (by NMR and MS). We adhere to relevant industry standards for reference materials. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. The product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D9)	≥ 98.0 atom % D
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.