Description

4,6-Dichloro-1A,2,3,7B-Tetrahydro-1-Oxa-Cyclopropa[A]Naphthalene is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused oxacyclopropane-naphthalene structure. This compound is critical for the synthesis of complex organic molecules, offering a versatile chiral building block for medicinal chemistry research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries seeking to introduce specific stereochemistry and functional complexity into target compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drug candidates.
• Agrochemical Synthesis: Serves as a precursor in the design and production of advanced pesticides and herbicides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of specialty polymers and organic electronic materials due to its rigid, fused-ring system.
• Asymmetric Catalysis: Employed as a ligand or a substrate in catalytic reactions to achieve high enantioselectivity in synthetic pathways.
• Academic & Industrial R&D: A valuable tool for methodological studies in organic synthesis, including cycloaddition and ring-opening reactions.

Basic Information

Product Name	4,6-Dichloro-1A,2,3,7B-Tetrahydro-1-Oxa-Cyclopropa[A]Naphthalene
CAS No.	939760-66-4
Molecular Formula	C11H8Cl2O
Molecular Weight	227.09 g/mol
Synonyms	4,6-Dichloro-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a]naphthalene; 1-Oxa-2,7b-dihydro-1H-cyclopropa[a]naphthalene, 4,6-dichloro-1a,2,3,7b-tetrahydro-; 4,6-Dichloro-1a,2,3,7b-tetrahydro-1-oxacyclopropa[a]naphthalene; 939760-66-4; 4,6-Dichloro-1-oxacyclopropa[a]naphthalene derivative; Oxacyclopropanaphthalene dichloro derivative
EINECS	Contact for details

Quality Control

Every batch of 4,6-Dichloro-1A,2,3,7B-Tetrahydro-1-Oxa-Cyclopropa[A]Naphthalene is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency meet the exacting standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.