Description

4-(3,4-Dichloro-Phenyl)-Pyrrolidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial importance. This compound serves as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), enabling the development of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex molecules for drug discovery and development programs.
• API Synthesis: Used as a building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and other therapeutic areas.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and the exploration of new chemical entities in academic and industrial R&D labs.
• Process Development: Serves as a standard or starting material for scaling up and optimizing synthetic routes in pilot plants and commercial manufacturing.
• Custom Synthesis: A foundational compound for contract research and manufacturing organizations (CROs/CMOs) producing bespoke intermediates for clients.

Basic Information

Product Name	4-(3,4-Dichloro-Phenyl)-Pyrrolidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
CAS No.	939758-01-7
Molecular Formula	C17H19Cl2NO4
Molecular Weight	372.24 g/mol
Synonyms	1-(tert-Butyl) 3-methyl 4-(3,4-dichlorophenyl)pyrrolidine-1,3-dicarboxylate; 4-(3,4-Dichlorophenyl)-1,3-pyrrolidinedicarboxylic Acid 1-(1,1-Dimethylethyl) Ester; 4-(3,4-Dichlorophenyl)pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester; tert-Butyl 4-(3,4-dichlorophenyl)-3-(methoxycarbonyl)pyrrolidine-1-carboxylate; 939758-01-7; 4-(3,4-Dichloro-Phenyl)-Pyrrolidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our 4-(3,4-Dichloro-Phenyl)-Pyrrolidine-1,3-Dicarboxylic Acid 1-tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and process chemistry. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.