Description

4-(3'-Fluoro)Phenyl-3-Carboxy-1-Boc-Pyrrolidine is a high-purity, advanced pharmaceutical intermediate featuring a protected pyrrolidine scaffold with a fluorinated aromatic moiety. This compound is specifically engineered for the synthesis of complex active pharmaceutical ingredients (APIs), where its structural elements are critical for modulating biological activity and pharmacokinetic properties. It is an essential building block for medicinal chemistry research and development, particularly in the creation of novel therapeutics targeting the central nervous system and other disease areas.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those requiring a fluorinated pyrrolidine core.
• Protease Inhibitor Development: Used in the research and production of inhibitors targeting various proteases, where the fluorophenyl and carboxylic acid groups are crucial for binding affinity.
• Peptidomimetic Chemistry: Serves as a constrained, non-natural amino acid analog for constructing peptidomimetics with enhanced metabolic stability and target selectivity.
• Library Synthesis for Drug Discovery: Employed in high-throughput and combinatorial chemistry to generate diverse compound libraries for biological screening.
• Agrochemical Research: Potential application as an intermediate in the development of advanced crop protection agents with novel modes of action.
• Material Science Precursor: Can be utilized in the synthesis of specialized ligands for catalysis or functional materials.

Basic Information

Product Name	4-(3'-Fluoro)Phenyl-3-Carboxy-1-Boc-Pyrrolidine
CAS No.	939757-99-0
Molecular Formula	C₁₇H₂₂FNO₄
Molecular Weight	323.36 g/mol
Synonyms	1-Boc-4-(3-fluorophenyl)-3-pyrrolidinecarboxylic acid; tert-Butyl 4-(3-fluorophenyl)-3-(carboxy)pyrrolidine-1-carboxylate; 4-(3-Fluorophenyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-3-carboxylic acid; 1-N-Boc-4-(3-fluorophenyl)-3-carboxypyrrolidine; 4-(3-Fluorophenyl)-3-carboxy-1-Boc-pyrrolidine; 4-(3-Fluorophenyl)-1-(tert-butoxycarbonyl)pyrrolidine-3-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(3'-Fluoro)Phenyl-3-Carboxy-1-Boc-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.