Description

trans-3-(tert-Butoxycarbonylamino)Cyclobutanecarboxylic Acid CAS NO 939400-34-7 is a high-purity, protected amino acid derivative featuring a conformationally constrained cyclobutane ring. This compound serves as a critical chiral building block in modern pharmaceutical synthesis, enabling the development of novel therapeutic agents with enhanced metabolic stability and potency. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of peptide mimetics, protease inhibitors, and other complex bioactive molecules.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Peptidomimetic Chemistry: Used to construct conformationally restricted peptide analogs, improving bioavailability and receptor selectivity.
• Protease Inhibitor Development: Serves as a core scaffold in the design of inhibitors for enzymes like proteases and kinases.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and enzyme mechanisms.
• Medicinal Chemistry: Facilitates structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Custom Synthesis: A starting material for the bespoke synthesis of complex molecules for preclinical and clinical research.

Basic Information

Item	Details
Product Name	trans-3-(tert-Butoxycarbonylamino)Cyclobutanecarboxylic Acid
CAS No.	939400-34-7
Molecular Formula	C10H17NO4
Molecular Weight	215.25 g/mol
Synonyms	Boc-3-Aminocyclobutanecarboxylic Acid (trans); (1r,3r)-3-[(tert-Butoxycarbonyl)amino]cyclobutanecarboxylic Acid; trans-N-Boc-3-aminocyclobutanecarboxylic Acid; (trans)-3-(Boc-amino)cyclobutanecarboxylic Acid; 3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic Acid (trans); (1R,3R)-rel-3-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclobutanecarboxylic Acid; trans-3-(Boc-amino)cyclobutanecarboxylic Acid; 939400-34-7
EINECS	Contact for details

Quality Control

Our trans-3-(tert-Butoxycarbonylamino)Cyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.