Description

n-Desmethylsulfonyl-N'-Methylsulfonyl Dofetilide is a key sulfonamide-based intermediate and reference standard of significant interest in advanced pharmaceutical research and development. This compound is critical for the synthesis and analytical characterization of dofetilide and related class III antiarrhythmic agents. It serves as an essential building block for medicinal chemists and quality control laboratories within the global pharmaceutical and fine chemical sectors, enabling precise drug development and rigorous impurity profiling.

Application

• Pharmaceutical Intermediate: A crucial synthetic precursor in the multi-step production of the antiarrhythmic drug Dofetilide and its structural analogs.
• Reference Standard: Used as a certified impurity standard or metabolite reference material for HPLC, LC-MS, and other analytical methods in pharmaceutical quality control (QC) and quality assurance (QA).
• Metabolite Studies: Employed in pharmacokinetic and drug metabolism research to study the biotransformation pathways of Dofetilide.
• Process Chemistry R&D: Utilized in route scouting, optimization, and scale-up studies for the development of robust and efficient synthetic processes.
• Regulatory Compliance: Supports regulatory filings (e.g., with FDA, EMA) by providing a characterized impurity for method validation and stability studies.
• Academic Research: Serves as a tool compound in university and institutional research focused on cardiac ion channel (IKr) modulation and structure-activity relationships (SAR).

Basic Information

Product Name	n-Desmethylsulfonyl-N'-Methylsulfonyl Dofetilide
CAS No.	937194-99-5
Molecular Formula	C19H24N2O5S2
Molecular Weight	424.53 g/mol
Synonyms	N-Desmethylsulfonyl-N'-Methylsulfonyl Dofetilide; Dofetilide Impurity; Dofetilide Related Compound; 4-[4-(Methylsulfonyl)phenyl]-2-phenyl-N-[2-[4-(methylsulfonyl)phenyl]ethyl]-1,2,3,6-tetrahydropyridine-5-carboxamide; 1,2,3,6-Tetrahydro-4-[4-(methylsulfonyl)phenyl]-2-phenyl-N-[2-[4-(methylsulfonyl)phenyl]ethyl]-5-pyridinecarboxamide; Dofetilide Sulfonamide Derivative; TK-Pharma Impurity 1 (Dofetilide); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our n-Desmethylsulfonyl-N'-Methylsulfonyl Dofetilide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets the high standards required for pharmaceutical R&D and reference standard applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.