Description

Lumacaftor (Vx-809) is a small-molecule corrector specifically designed to address the underlying cellular processing defect in cystic fibrosis. This compound matters as a key pharmaceutical intermediate and research tool for developing therapies targeting the F508del-CFTR mutation. It is essential for pharmaceutical R&D teams, contract research organizations (CROs), and manufacturers engaged in the development and production of next-generation CFTR modulator therapies.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis of advanced combination therapies for cystic fibrosis.
• Biomedical Research: Used as a reference standard and active investigational compound in preclinical studies of CFTR protein trafficking and function.
• Drug Discovery & Development: Serves as a lead compound and pharmacophore model for designing novel corrector molecules.
• Academic Research: Utilized in university and institutional labs studying the molecular pathology of cystic fibrosis and protein-folding diseases.
• Quality Control & Analytical Testing: Employed as an analytical reference standard for HPLC, LC-MS, and NMR methods in pharmaceutical quality assurance.

Basic Information

Product Name	Lumacaftor (Vx-809)
CAS No.	936727-05-8
Molecular Formula	C₂₄H₁₈F₂N₂O₅
Molecular Weight	452.41 g/mol
Synonyms	VX-809; 3-[6-[[1-(2,2-Difluoro-1,3-benzodioxol-5-yl)cyclopropanecarbonyl]amino]-3-methylpyridin-2-yl]benzoic acid; N-[2-(4-Hydroxy-2,6-dimethylphenyl)amino]-2-oxoethyl]-N-methylglycine; Lumacaftor impurity; CFTR corrector VX-809; 1-(2,2-Difluoro-1,3-benzodioxol-5-yl)-N-[6-(3-hydroxybenzoyl)-2-methylpyridin-3-yl]cyclopropanecarboxamide (non-preferred IUPAC); VX 809
EINECS	Contact for details

Quality Control

Our Lumacaftor (VX-809) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.