Description

Tramazoline CAS NO 1082-57-1 is a synthetic imidazoline derivative with potent vasoconstrictive properties. This compound is a key active pharmaceutical ingredient (API) primarily valued for its decongestant effects in topical nasal and ophthalmic formulations. It is essential for pharmaceutical manufacturers developing specialized over-the-counter (OTC) and prescription medications targeting nasal congestion and ocular redness. The high purity and consistent quality of this intermediate are critical for ensuring the safety and efficacy of the final drug product.

Application

• Active Pharmaceutical Ingredient (API) in nasal decongestant sprays and drops.
• Key Intermediate for the synthesis of ophthalmic solutions used to relieve eye redness.
• Research Chemical in pharmacological studies investigating α-adrenergic receptor agonists.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Starting Material for the preparation of novel derivatives in medicinal chemistry research.

Basic Information

Product Name	Tramazoline
CAS No.	1082-57-1
Molecular Formula	C₁₃H₁₇N₃
Molecular Weight	215.30 g/mol
Synonyms	2-[(1,2,3,4-Tetrahydro-1-naphthalenyl)amino]-2-imidazoline; Tramazoline Hydrochloride (salt form); Tramazolin; Decongestant 1082-57-1; Vasoconstrictor 1082-57-1; 2-(1,2,3,4-Tetrahydro-1-naphthylamino)-2-imidazoline; 2-Imidazolinamine, N-(1,2,3,4-tetrahydro-1-naphthalenyl)-
EINECS	214-122-6

Quality Control

Our Tramazoline is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical intermediates. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC and other pharmacopeial methods. A Certificate of Analysis (COA) detailing all test results is provided to guarantee traceability and compliance with relevant industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.