Description

Oxymetazoline Hydrochloride is a potent, selective α-adrenergic agonist widely recognized for its vasoconstrictive properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of nasal decongestant formulations. It is primarily utilized by pharmaceutical manufacturers and R&D laboratories in the development and production of over-the-counter (OTC) and prescription nasal sprays, drops, and ophthalmic solutions.

Application

• Primary Pharmaceutical Ingredient: The key API in topical nasal decongestant sprays and drops for temporary relief of nasal congestion due to allergies, sinusitis, or the common cold.
• Ophthalmic Solutions: Used in formulations to relieve redness of the eye due to minor irritations.
• Veterinary Medicine: Employed in topical preparations for nasal and ophthalmic use in animals.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological studies targeting α-adrenergic receptors.
• Formulation Development: Used by product development scientists to create new delivery systems, such as gels or sustained-release formulations.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of branded and generic medicinal products.

Basic Information

Product Name	Oxymetazoline Hydrochloride
CAS No.	2315-02-8
Molecular Formula	C16H24N2O·HCl
Molecular Weight	296.84 g/mol
Synonyms	6-tert-Butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol hydrochloride; Afrin (active ingredient); Nafrine; Drixine; 2-[(4-tert-Butyl-2,6-dimethylbenzyl)oxy]-4,5-dihydro-1H-imidazole hydrochloride; Oxymetazoline HCl; 2315-02-8
EINECS	219-025-6

Quality Control

Our Oxymetazoline Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Specific Rotation	-0.10° to +0.10° (c = 1 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.