Description

Vx-770 is a high-purity, small-molecule pharmaceutical intermediate and research chemical. This compound is critical for the development and production of targeted therapeutics, particularly in the field of cystic fibrosis research. It is essential for pharmaceutical manufacturers, advanced research institutions, and fine chemical suppliers requiring a reliable source of a key active pharmaceutical ingredient (API) intermediate.

Application

• Pharmaceutical API Synthesis: A key intermediate in the production of Ivacaftor, a CFTR potentiator used in the treatment of cystic fibrosis.
• Biomedical Research: Used as a reference standard and active compound in preclinical studies targeting CFTR protein function.
• Process Development & Scale-up: Serves as a critical building block for process chemistry teams optimizing synthetic routes for GMP manufacturing.
• Analytical Standard: Employed as a high-purity standard for method development and validation in quality control laboratories (e.g., HPLC, LC-MS).
• Fine Chemical Production: Utilized in the synthesis of more complex, specialized molecules for targeted drug discovery programs.

Basic Information

Product Name	Vx-770
CAS No.	121911-71-5
Molecular Formula	C24H28N2O3
Molecular Weight	392.49 g/mol
Synonyms	Ivacaftor Intermediate; N-(2,4-Di-tert-butyl-5-hydroxyphenyl)-1,4-dihydro-4-oxoquinoline-3-carboxamide; 3-Quinolinecarboxamide, N-(2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl)-1,4-dihydro-4-oxo-; VX-770; Vertex-770; Lumacaftor/VX-809 related compound; CFTR Potentiator Intermediate
EINECS	Contact for details

Quality Control

Our Vx-770 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to industry best practices and can support development toward cGMP standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.