Description

Oxymetazoline is a potent, long-acting imidazoline derivative with direct sympathomimetic activity, primarily functioning as a selective α-1 adrenergic receptor agonist. This compound is of critical importance in pharmaceutical manufacturing for its potent vasoconstrictive properties, which provide rapid and sustained relief from nasal congestion. It is an essential active pharmaceutical ingredient (API) for producers of over-the-counter (OTC) and prescription nasal decongestant sprays, as well as ophthalmic solutions.

Application

• Primary Pharmaceutical Ingredient: Core API in topical nasal decongestant sprays for the symptomatic relief of nasal congestion associated with rhinitis, sinusitis, and the common cold.
• Ophthalmic Solutions: Used in eye drop formulations to relieve redness (ocular vasoconstriction) caused by minor irritations.
• Veterinary Pharmaceuticals: Employed in veterinary medicine for similar decongestant purposes in animals.
• Research & Development: Serves as a reference standard and key intermediate in pharmacological research focused on adrenergic receptors and vasoactive compounds.
• Formulation Development: Used by generic drug manufacturers in the development and production of bioequivalent nasal spray products.

Basic Information

Product Name	Oxymetazoline
CAS No.	1491-59-4
Molecular Formula	C16H24N2O
Molecular Weight	260.38 g/mol
Synonyms	Oxymetazoline Hydrochloride (common salt form); 6-tert-Butyl-3-[(4,5-dihydro-1H-imidazol-2-yl)methyl]-2,4-dimethylphenol; Afrazine; Nafrine; Drixine; Duration; 4H-Imidazole, 4,5-dihydro-2-(1,1-dimethylethyl)-6-(2-hydroxyethyl)-3-methyl-5-(1-methylethyl)-, hydrochloride; 2-[(4-tert-Butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole
EINECS	Contact for details

Quality Control

Our Oxymetazoline is manufactured under strict quality management systems, targeting purity levels suitable for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure compliance with in-house specifications and relevant pharmacopeial guidelines. A Certificate of Analysis (COA) documenting all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.